单自由度八杆仿生机构构型与尺度同步设计方法

单自由度八杆仿生机构杆长参数较多，是仿生机器人领域研究的难点之一。为提高设计效率，提出一种构型与尺度同步设计方法。在选定的运动链和机架的基础上，以不等式形式分步给出运动可行性及外形约束条件，使得上一步的杆长可作为下一步求解的已知值。通过该过程，在得到八杆仿生机构构型的同时，快速得到所有杆长的初步可行域。循环上述过程，逐步缩小约束条件的范围，可使得八杆机构的杆长快速接近目标值。在此基础上，分类讨论了连杆搭接顺序、约束条件及基本运动链的差异对求解难度及构型结果的影响。利用所提出的单自由度八杆仿生机构的设计方法，在对初始条件进行合理选取的前提下，可在初步得到构型的同时将杆长限定在较小范围内，实现了构型与尺度的同步设计。该方法还可应用于其他单自由度机构的设计当中，具有较好的借鉴意义。     

镀液温度实时控制系统的设计与实现

针对镀液温度变化的非线性和滞后性,设计了采用专家规则的镀液温度实时控制系统。该系统在实时监测的基础上,构建了综合评判镀液温度偏差和镀液温度偏差变化率的专家规则,实现了镀液温度的自适应快速调节。仿真分析结果表明,该系统克服了非线性和滞后性的不良影响,能够实现镀液温度的实时控制。     

露天爆破智能设计系统开发及应用

为了提高露天台阶爆破设计的规范化、便捷性，对露天台阶爆破设计系统进行了开发研究。以Visual C++为开发平台，软件采用MFC框架，结合OpenGL三维引擎开发技术，实现软件从底层自主开发生态的建立。通过现场工程实践应用表明爆破设计人员可以轻松通过本系统实现三维环境下的布孔设计和爆破网络设计以及精确的GPS布孔，并取得了良好的爆破效果，提高了台阶爆破的设计质量和设计速度。爆破智能设计系统能够实现矿山爆破设计的数字化、科学化、自动化和高效化，对于露天爆破具有十分重要的意义。     

Design structure matrix (DSM) method application to issue of modeling and analyzing the fault tree of a wind energy asset

The perpetual energy production of a wind farm could be accomplished (under proper weather conditions) if no failures occurred. But even the best possible design, manufacturing, and maintenance of a system cannot eliminate the failure possibility. In order to understand and minimize the system failures, the most crucial components of the wind turbines, which are prone to failures, should be identified. Moreover, it is essential to determine and classify the criticality of the system failures according to the impact of these failure events on wind turbine safety. The present study is processing the failure data from a wind farm and uses the Fault Tree Analysis as a baseline for applying the Design Structure Matrix technique to reveal the failure and risk interactions between wind turbine subsystems. Based on the analysis performed and by introducing new importance measures, the “readiness to fail” of a subsystem in conjunction with the “failure riskiness” can determine the “failure criticality.” The value of the failure criticality can define the frame within which interventions could be done. The arising interventions could be applied either to the whole system or could be focused in specified pairs of wind turbine subsystems. In conclusion, the method analyzed in the present research can be effectively applied by the wind turbine manufacturers and the wind farm operators as an operation framework, which can lead to a limited (as possible) design‐out maintenance cost, failures' minimization, and safety maximization for the whole wind turbine system.     

单一低渗透突出煤层水力冲孔工艺优化应用分析

为了有效提高单一低渗透突出煤层的瓦斯抽采效率，以高压水射流冲击理论为指导，针对平煤股份八矿己组突出煤层特征建立数值模型，模拟分析水力冲孔应力分布规律，通过现场实测分析冲孔有效影响范围，进一步优化设计冲孔参数、指导现场施工。现场应用表明，水力冲孔是一种行之有效的方法，对单一低渗透突出煤层实施水力冲孔卸压增透、提高瓦斯抽采效果具有重要意义。     

从中西色彩观差异看中西方设计色彩的异与同

目的对中西方设计色彩差异进行理论分析。方法以中西色彩表达的文化差异为基础,通过对中西方色彩观的文化渊源进行比较分析,提炼出对中西传统色彩观的文化特点概括。结论通过对色彩在中西方建筑、服饰、装饰等设计中的运用案例进行分析,把握传统色彩观在历史空间中的演进与中西融合趋势,以求对21世纪全球语境下的现代设计色彩发展,提供基于中西传统色彩观特点比较分析基础上的把握。     

Kinetic,thermodynamic parameters and in vitro digestion of tannase from Aspergillus tamarii URM 7115

Tannase is an enzyme used in various industries and produced by a large number of microorganisms. The aim of this study was to evaluate tannase production to determine the biochemical, kinetic, and thermodynamic properties and to simulate tannase in vitro digestion. The tannase-producing fungal strain was isolated from “jamun” leaves and identified as Aspergillus tamarii. Temperature at 26°C for 67?h was the best combination for maximum tannase activity (6.35-fold; initial activity in Plackett–Burman design—15.53?U/mL and average final activity in Doehlert design—98.68?U/mL). The crude extract of tannase was optimally active at 40°C, pH 5.5 and 6.5. Moreover, tannase was stimulated by Na⁺, Ca²⁺, Mg²⁺, and Mn²⁺. The half-life at 40°C lasted 247.55?min. The free energy of Gibbs, enthalpy, and entropy, at 40°C, was 81.47, 16.85, and ?0.21?kJ/mol?·?K, respectively. After total digestion, 123.95% of the original activity was retained. Results suggested that tannase from A. tamarii URM 7115 is an enzyme of interest for industrial applications, such as gallic acid production, additive for feed industry, and for beverage manufacturing, due to its catalytic and thermodynamic properties.     

精密磨床转台静压轴承的强健化设计

针对精密磨床转台静压轴承性能仿真数据与其回转精度实测数据不一致的问题，为提高转台静压轴承的设计水平，提出了静压轴承的强健化设计方法。该方法考虑了轴承结构参数在轴承全生命周期内的变化，分析了半径间隙、油腔尺寸、节流比及润滑油黏度在设计、加工、装配和服役4个阶段的变化规律，重点研究了半径间隙在各阶段对轴承性能造成的影响，给出了转台静压轴承的强健化设计流程。通过一个径向轴承的设计实例对该强健化设计方法进行了说明，并将设计结果与传统设计进行了对比。对比的指标是轴承在4个阶段的刚度、承载力和温升，这3个指标对轴承回转精度有直接影响。研究表明：进行强健化设计后，在生命周期内静压轴承的刚度和承载力的变化量为10%~27%，温度的变化量为0.5%~1.6%，较传统设计更能保证转台回转精度的稳定。     

深部大采高工作面煤柱留设优化数值模拟研究

为缓解高产高效矿井采掘接续紧张局面，鄂尔多斯地区综采工作面多采用“两进一回”的巷道布置形式，辅运巷在回采结束后用作下一工作面的回风巷，两进风巷之间采用大煤柱护巷。但随着该地区采深600 m以上的深部矿井增多，冲击地压灾害问题逐渐显现，双巷大煤柱留设的弊端也暴露出来。针对此问题，以鄂尔多斯红庆河煤矿3^-1101大采高综采工作面为例，对不同宽度煤柱留设的应力分布规律进行建模研究，提出了合理的煤柱留设宽度，为鄂尔多斯地区类似条件矿井的安全高效开采提供参考依据。     

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs

The orexin system is responsible for regulating the sleep-wake cycle. Suvorexant, a dual orexin receptor antagonist (DORA) is approved by the FDA for the treatment of insomnia disorders. Herein, we report the optimization efforts toward a DORA, where our starting point was (5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}methanone ( 6 ), a compound which emerged from our in-house research program. Compound 6 was shown to be a potent, brain-penetrating DORA with in vivo efficacy similar to suvorexant in rats. However, shortcomings from low metabolic stability, high plasma protein binding (PPB), low brain free fraction (f_u brain), and low aqueous solubility, were identified and hence, compound 6 was not an ideal candidate for further development. Our optimization efforts addressing the above-mentioned shortcomings resulted in the identification of (4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}l-methanone ( 42 ), a DORA with improved in vivo efficacy compared to 6 .